Professor Arye Nehorai with his students and collaborators Professor Samuel Achilefu from the Washington University School of Medicine, Professor Axel Scherer of Caltech and Professor Zhenyu Li of George Washington University are developing a microfluidic microsphere-trap array device. The device will be used to detect and quantify the protein, DNA, and mRNA expressions of tumor cells, for predicting the proliferation of tumors. The device will have position-encoded microspheres that will enable simultaneous and error-free identification of multiple targets. The geometry of the device has been optimized to maximize the microsphere arrays' packing density, enhance microsphere-trapping efficiency, and eliminate fluidic errors, while guaranteeing a desired statistical imaging performance.
Professor Nehorai leads the multi-university NSF grant "CIF: IHCS: Medium: Collaborative Research: Design and Implementation of Position-Encoded 3D Microarrays" that supports this work.